Abstract: Disordered glycolipid metabolism is the core pathological basis of metabolic diseases such as type 2 diabetes mellitus (T2DM) and obesity, and the epigenetic regulatory factor bromodomain-containing protein 4 (BRD4) plays a key role in this process. This article systematically reviews the molecular mechanisms by which BRD4 regulates glycolipid metabolism through epigenetic regulation, signaling pathway crosstalk, and organ-specific regulatory networks, as well as its pathological role and therapeutic potential in metabolic diseases.
Keywords: BRD4; glucose metabolism; lipid metabolism; epigenetic regulation; insulin signaling pathway
（Acta Laser Biology Sinica, 2026, 35(4): 310-318）