Abstract: Photobiomodulation (PBM), as a rapidly developing branch of translational medicine research, possesses characteristics such as being non-invasive, safe, painless, and biomodulating. PBM has been widely used in the treatment of diseases such as wound healing, chronic pain relieving, and skeletal muscle regeneration. In recent years, it has received special attention in the treatment of neurodegenerative diseases such as Alzheimer’s disease (AD). However, there is currently a lack of systematic summaries of the molecular mechanisms and clinical research on PBM’s regulation of different types of nerve cell functions in the treatment of AD. Given this situation, this article reviews the potential mechanisms of action and clinical research progress of PBM in the treatment of AD, starting from the regulation of different cell types, including neurons, astrocytes, microglia and neural stem cells, providing a theoretical basis for the development of non-invasive, non-toxic new AD treatment technologies and their clinical translational applications.
Key words: photobiomodulation; Alzheimer’s disease; neurodegenerative diseases; different neural cell functions; clinical application
（Acta Laser Biology Sinica, 2026, 35(2): 130-140）