Semiconductor Singlewalled Carbon Nanotubes for Deep Tissues NearInfraredII Photoacoustic Imaging

CUI Dandan, SHI Yujiao

Acta Laser Biology Sinica ›› 2019, Vol. 28 ›› Issue (5) : 463-467.

PDF(1641 KB)
PDF(1641 KB)
Acta Laser Biology Sinica ›› 2019, Vol. 28 ›› Issue (5) : 463-467.

Semiconductor Singlewalled Carbon Nanotubes for Deep Tissues NearInfraredII Photoacoustic Imaging

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Abstract

The optical absorption of exogenous contrast agents in conventional photoacoustic imaging is mainly concentrated in the visible region and the traditional near infrared region (NIR, 750~900 nm). The development of nearinfrared-II (NIR-II, 1 000~1 700 nm) nanoprobes with higher optical tissue penetration depth is of great significance for photoacoustic imaging of deep tissue in vivo. In this paper, semiconductor singlewalled carbon nanotubes with optical absorption peaks of about 1 000 nm were selected as the exogenous contrast agent for nearinfraredⅡphotoacoustic imaging. The strong photoacoustic effect was tested under nearinfraredⅡlaser excitation. Furthermore, the deep photoacoustic imaging of the phantom tissue was obtained by embedding the nanomaterial in different depths of the tissuemimic phantom. The imaging depth can reach 1.5 cm. Experimental results show that semiconductor singlewalled carbon nanotubes (SWCNTs) with nearinfraredⅡ optical absorption have great potential in photoacoustic imaging of deep tissues in vivo. 

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CUI Dandan, SHI Yujiao. Semiconductor Singlewalled Carbon Nanotubes for Deep Tissues NearInfraredII Photoacoustic Imaging[J]. Acta Laser Biology Sinica. 2019, 28(5): 463-467
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