Eighty four patients with cafeaulait were treated with Qswitched 532 nm or 755 nm laser randomly by our center. The clinical efficacy was assessed. 36 patients were treated with Qswitched 532 nm laser, 10 patients were completely cured (27.8%), 10 patients were significantly improved (27.8%), 8 improved (22.2%) and 8 invalid (22.2%); 48 patients were treated with Qswitched 755 nm laser, 14 patients were cured completely (29.2%), 13 patients were significantly improved (27.1%), 11 improved (22.9%) and 10 invalid (20.8%). Of the 84 patients, total effective rate is 78.6%. After 6 months of followup, 9 patients appeared pigmentation, 3 patients appeared hypopigmentation and 9 recrudesced. The effective rate of cafeaulait with regular shape is 52.5%, and irregular shape is 79.5%, there was a significant difference between two teams (P＜0.05). There was no significant difference in efficacy between Qswitched 532 nm and 755 nm laser (P＞0.05). The above results showed  Qswitched 532 nm and 755 nm laser were effective agents for treatment of  cafeaulait.，and the efficacy of Qswitched laser on cafeaulait with regular shape is better than those with irregular shape．