An Experimental Study on the Inactivation of HL60 Cells in vitro #br# Photodynamic Therapy Based on Fe-TiO2 and Ni-TiO2

Acta Laser Biology Sinica ›› 2018, Vol. 27 ›› Issue (6) : 522-529.

PDF(5821 KB)
PDF(5821 KB)
Acta Laser Biology Sinica ›› 2018, Vol. 27 ›› Issue (6) : 522-529.

An Experimental Study on the Inactivation of HL60 Cells in vitro #br# Photodynamic Therapy Based on Fe-TiO2 and Ni-TiO2

Author information +
History +

Abstract

In this paper, Fe-TiO2 and Ni-TiO2 nanoparticles were synthesized by solgel method. The inactivation of HL60 cells in vitro photodynamic therapy was studied. The nanoparticles were characterized by transmission electron microscope (TEM), energy dispersive spectrometer(EDS), Xray diffraction (XRD), ultravioletvisible (UVVis) absorption spectrum etc. The inactivation of HL60 cells by Fe-TiO2 and Ni-TiO2 was analyzed by CCK-8 assay. The experimental results show that Fe-TiO2 and Ni-TiO2 nanoparticles with different final concentration and doping amount have lower dark toxicity to HL60 cells, but the PDT efficiency is significantly higher than that of pure TiO2. Under the optimal parameters, the PDT inactivation efficiency reached 72.5%±1.6% and 56.4%±1.2% respectively. In addition, the differences in the inactivation effects of these two nanoparticles were also discussed.

Cite this article

Download Citations
An Experimental Study on the Inactivation of HL60 Cells in vitro #br# Photodynamic Therapy Based on Fe-TiO2 and Ni-TiO2[J]. Acta Laser Biology Sinica. 2018, 27(6): 522-529
PDF(5821 KB)

Accesses

Citation

Detail

Sections
Recommended

/