Linear Confocal Photoacoustic Microscopy for Detection of Chromatodermatosis

Acta Laser Biology Sinica ›› 2018, Vol. 27 ›› Issue (5) : 423-427.

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PDF(2301 KB)
Acta Laser Biology Sinica ›› 2018, Vol. 27 ›› Issue (5) : 423-427.

Linear Confocal Photoacoustic Microscopy for Detection of Chromatodermatosis

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Abstract

Medical imaging plays an indispensable role in clinical diagnosis and assessment of pathophysiological correlations in dermatology. However, the existing imaging techniques are limited to properly acquire the concentration and spatial distribution of skin melanin for chromatodermatosis. In this work, a linear confocal scanning photoacoustic microscopy was developed for labelfree visualizing the pathologic structures of pigmented lesion and quantitatively evaluating melanin content of pigmented abnormality. The system was utilized for noninvasive and highresolution imaging of epidermal conditions in Cafeaulait macules patients. Image results demonstrated that there was a significant difference between normal and Cafeaulait macules skin. By implementing a linear confocal scanning mode, an individual〖DK〗’s photoacoustic pathological section can be quickly obtained with clinical score in 1 s. The photoacoustic microscopy might as well extend to diagnose other dermatological conditions, which opens a perspective in dermatological imaging technology.

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Linear Confocal Photoacoustic Microscopy for Detection of Chromatodermatosis[J]. Acta Laser Biology Sinica. 2018, 27(5): 423-427
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