Linear Confocal Photoacoustic Microscopy for Detection of Chromatodermatosis
Author information+
Show less
History+
Published
2018-10-29
Just Accepted Date
Issue Date
2025-07-17
2018-10-29
Abstract
Medical imaging plays an indispensable role in clinical diagnosis and assessment of pathophysiological correlations in dermatology. However, the existing imaging techniques are limited to properly acquire the concentration and spatial distribution of skin melanin for chromatodermatosis. In this work, a linear confocal scanning photoacoustic microscopy was developed for labelfree visualizing the pathologic structures of pigmented lesion and quantitatively evaluating melanin content of pigmented abnormality. The system was utilized for noninvasive and highresolution imaging of epidermal conditions in Cafeaulait macules patients. Image results demonstrated that there was a significant difference between normal and Cafeaulait macules skin. By implementing a linear confocal scanning mode, an individual〖DK〗’s photoacoustic pathological section can be quickly obtained with clinical score in 1 s. The photoacoustic microscopy might as well extend to diagnose other dermatological conditions, which opens a perspective in dermatological imaging technology.