In order to evaluate the toxicological safety of oligopeptides and vitamin C compound in solid drink. Toxicological and safety assessments were conducted, according to the Technical Standards for Testing and Assessment of Health Food by Healthy Ministry 2003, the results showed that the maximum tolerated dose of oligopeptides and vitamin C compound in solid drink on mice was more than 20 g/kg. BW. Therefore, the sample fell into the scale of nontoxicity. The genotoxicity tests including Ames test，bone marrow cell micronucleus，sperm shape abnormality were all negative. The results of 30days test showed that the animals of control group and each dose group were well developed, without death and abnormal clinical sign. The body weight, food intake  food utilization rate, organ weight, organ / body ratios, hematological parameters and blood biochemical indexes had no significant difference (P>0.05) between the control group and the treatment groups. There are no abnormal pathological changes in liver, kidney, stomach, intestine, spleen,testicle and ovary of rats in treatment group. The conclusion is that the oligopeptides and vitamin C compound in solid drink are safe with no evident toxic effect.