摘 要：光生物调节疗法（PBMT）作为一种非侵入性、低成本、低风险的治疗技术，在溃疡性结肠炎（UC）的治疗领域展现出独特的应用前景。本文介绍了UC的发病机制及PBMT在临床中的应用现状，分析后认为，该疗法有望与5-氨基水杨酸（5-ASA）制剂、生物制剂等现有治疗手段发挥协同作用。同时，本文也深入分析了PBMT在临床应用中可能存在的挑战与安全风险，建议未来的研究应聚焦于制定操作方式、调整治疗参数、开发个体化治疗方案、加设安全措施等方面，以推动PBMT在UC治疗中的临床转化。
关键词：生物光学；光生物调节疗法；低能量光源；溃疡性结肠炎；治疗技术
中图分类号：R454.2                        文献标志码：A                    DOI：10.3969/j.issn.1007-7146.2025.04.002

Abstract: As a non-invasive, low-cost and low-risk treatment technology, photobiomodulation therapy (PBMT) shows a unique application prospect in the treatment of ulcerative colitis (UC). This article introduces the pathogenesis of UC and the current application status of PBMT in clinical practice. It is analyzed that this therapy is expected to play a synergistic role with existing treatment methods such as 5-aminosalicylic acid (5-ASA) preparations and biological agents. At the same time, this article also analyzes deeply the possible challenges and safety risks in the clinical application of PBMT. It is recommended that future research should focus on formulating operation methods, adjusting treatment parameters, developing individualized treatment plans, and adding safety measures, so as to promote the clinical transformation of PBMT in the treatment of UC.
Key words: biological optics; photobiomodulation therapy; low energy light source; ulcerative colitis; treatment
（Acta Laser Biology Sinica, 2025, 34(4): 296-303）