摘　要：闭塞性支气管炎是一种肺部纤维化疾病，在吸入有害气体、免疫功能紊乱和肺或骨髓移植等情况下会发生。纤维化是闭塞性支气管炎的病理标志，其力学特性的改变对理解闭塞性支气管炎的病理进展起到关键作用。由于缺乏对闭塞性支气管炎力学特性的相关研究，人们对这方面的病理机制知之甚少。因此，本文针对上述问题，采用光声遥感弹性成像技术对支气管纤维化生物力学特性进行成像研究。结果表明，正常支气管以及纤维化早、中、晚期支气管对应的光声信号上升时间分别为113、107、96 ns和70 ns，上升时间短则弹性模量大，纤维化支气管弹性模量比正常支气管弹性模量大，纤维化三个阶段的弹性模量从早期到晚期依次增大。本文对闭塞性支气管炎进程中的支气管力学特性变化进行了研究，并且对其弹性模量相对值进行提取，为闭塞性支气管炎分级诊断和防治提供了一种新的参考。
关键词：生物光学；光声成像；弹性成像；光声遥感；支气管纤维化
中图分类号：O436　　　　　　　文献标志码：ADOI：10.3969/j.issn.1007-7146.2025.03.006

Abstract: Obstructive bronchitis is a fibrotic disease of the lungs that occurs in response to inhalation of noxious gases, immune dysfunction and lung or bone marrow transplantation. Fibrosis is a pathological hallmark of obstructive bronchitis, and alterations in its mechanical properties play a key role in understanding the pathological progression of obstructive bronchitis. Due to the lack of studies related to the mechanical properties of obstructive bronchitis, little is known about the pathological mechanisms in this area. Therefore, in this paper, to address the above problem, photoacoustic remote sensing elastography was used to image the biomechanical properties of bronchial fibrosis. The results showed that the rise times of photoacoustic signals corresponding to normal bronchial tubes as well as bronchial tubes in the early, middle, and late stages of fibrosis were 113 ns, 107 ns, 96 ns, and 70 ns, respectively, and a short rise time resulted in a large elastic modulus; the elastic modulus of fibrotic bronchial tubes was larger than that of normal bronchial tubes, and the elastic modulus in the three stages of fibrosis increased sequentially from the early stage to the late stage. In this paper, the changes of bronchial mechanical properties during the process of obstructive bronchitis were investigated and the relative values of elastic modulus were extracted to propose a new reference for the graded diagnosis and prevention of obstructive bronchitis.
Key words: biological optics; photoacoustic imaging; elastic imaging; photoacoustic remote sensing; bronchial fibrosis
（Acta Laser Biology Sinica, 2025, 34(3): 239-245）