摘　要：光动力疗法（PDT）作为一种非药物治疗手段，在多种疾病的治疗中展现出良好的效果和较低的副作用，具有广阔的应用前景。近年来，PDT在消化系统疾病的诊断与治疗中日益重要，尤其是在消化道肿瘤和胃肠道炎症的治疗方面。本文综述了PDT在治疗各类消化系统疾病中的研究进展和临床应用情况，通过文献回顾，总结出PDT治疗不同类型消化系统疾病的优势，并探讨其在临床应用中的局限性，展望PDT在医学诊断和治疗中的发展方向，提出光敏剂（PS）技术创新以及将其作为其他疾病常规治疗方式的可能性。尽管面临一定的限制，但PDT在临床应用中的发展前景依然广阔，有望为疾病治疗提供新的方向和思路。
关键词：光动力疗法；光敏剂技术；消化系统疾病；诊断和治疗；应用研究
中图分类号：R735　　　　  文献标志码：A        DOI：10.3969/j.issn.1007-7146.2025.03.001

Abstract: As a non-drug treatment, photodynamic therapy (PDT) has shown good effects and low side effects in the treatment of a variety of diseases, and has broad application prospects. In recent years, PDT has become increasingly important in the diagnosis and treatment of digestive system diseases, especially in the treatment of gastrointestinal tumors and gastrointestinal inflammation. This article reviews the research progress and clinical applications of PDT in the treatment of various digestive diseases. Through literature review, the advantages of PDT in the treatment of different types of digestive diseases are summarized, and the limitations of its clinical applications are discussed. The development direction of PDT in medical diagnosis and treatment is projected, and the technological innovation of photosensitizer and the possibility of its use as a routine treatment for other diseases are proposed. Despite some limitations, the development prospects of PDT in clinical application are still broad, and it is expected to provide new directions and ideas for the treatment of diseases.
Key words: photodynamic therapy; photosensitizer technology; digestive system diseases; diagnosis and treatment; application research
（Acta Laser Biology Sinica, 2025, 34(3): 193-206）