摘　要：糖脂转运蛋白（GLTP）是调控机体各类糖鞘脂（GSLs）在细胞质膜内外转运的关键蛋白。研究表明：GLTP在宫颈癌（CC）中可能通过巨噬细胞接口和肿瘤浸润淋巴细胞对肿瘤微环境中的免疫状态进行调控，显示出抑癌作用，且能够预测CC患者的生存期，并有潜力成为药物治疗靶点，但GLTP在CC中的具体作用机制还未见报道；在结直肠癌（CRC）细胞中，miR-196b上调直接靶向GLTP mRNA，下调其蛋白质的表达水平，而GLTP的过表达可通过干预细胞周期进程和鞘脂代谢诱导某些CRC细胞的坏死性凋亡，表明GLTP有望成为CRC精准治疗的重要靶点和预后标志物；此外，GLTP可以通过核因子红细胞2相关因子2（NRF2）/miR-196a/GLTP通路调控非小细胞肺癌（NSCLC）细胞对酪氨酸激酶抑制剂（TKIs）吉非替尼的耐药性，其表达水平与肿瘤分级和病患生存期相关，GLTP可能是NSCLC细胞对TKIs耐药的新生物标志物和治疗靶点。综上所述，GLTP在多类肿瘤中的作用具有显著的临床价值，有望为癌症的临床治疗、预后评估等提供新的方向。
关键词：糖脂转运蛋白；肿瘤；凋亡；预后；临床治疗
中图分类号：R73　　　　　　　文献标志码：A　　　　　　DOI：10.3969/j.issn.1007-7146.2025.02.002

Abstract: Human glycolipid transport protein (GLTP) is a key protein that regulates the transport of different types of glycosphingolipids (GSLs) into and out of the cytoplasmic membrane of the organism. Studies have shown that in cervical cancer (CC), GLTP may regulate the immune status in the tumor microenvironment through the interface between macrophages and tumor-infiltrating lymphocytes, exerting an oncostatic effect and being able to prognosticate the survival of CC patients, with the potential to be a therapeutic drug target, whereas the specific mechanism of action of GLTP in CC has not yet been reported. In colorectal cancer (CRC) cells, the upregulation of miR-196b directly targets GLTP mRNA to downregulate its protein expression level, and the overexpression of GLTP can induce necrotic apoptosis in some CRC cells by interfering with cell cycle progression and sphingolipid metabolism, suggesting that GLTP is expected to be an important target and prognostic marker for precision therapy of CRC. Furthermore, GLTP has been demonstrated to regulate the resistance of non-small cell lung cancer (NSCLC) cells to tyrosine kinase inhibitors (TKIs) gefitinib via the nuclear factor erythroid 2-related factor 2 (NRF2)/miR-196a/GLTP pathway, its expression level has been shown to correlate with tumor grading and patient survival. GLTP may serve as a novel biological marker and therapeutic target for NSCLC cells resistant to TKIs. In conclusion, the role of GLTP in various types of tumors is of great clinical value and is expected to provide new directions for clinical treatment and prognosis assessment of cancer.
Key words: GLTP; tumor; apoptosis; prognosis; clinical treatment
（Acta Laser Biology Sinica, 2025, 34(2): 107-112）