摘　要：近红外（NIR）光诱导的光热治疗（PTT）因其无创、非侵入、毒副作用低、可精准靶向治疗等特性，已成为肿瘤精准治疗的新型手段。凭借其独特的表面等离激元共振（SPR）特性及其高效的光热转换效率、生物毒性与良好的光稳定性，金纳米颗粒（Au NPs）已成为理想的光热治疗剂。而高质量成像技术是实现有效光热治疗的可靠有力的工具，尤其是多模态成像技术，比起单一成像方式具有更卓越的性能，为更全面、更精准的肿瘤成像提供了可能，显著提高了非侵入性医学治疗的潜力。NIR光激发的稀土上转换纳米颗粒（UCNPs），因其丰富的4f电子结构展现出磁性、荧光、X射线衰减和放射等多功能特性，使其作为造影剂在多模态成像领域展现了重要的应用前景。因此， 构建NIR光诱导的 Au NPs/UCNPs复合纳米体系，可用于多模态成像引导下的光热治疗，有望成为癌症诊疗的一种新策略。本文简单介绍了Au NPs、UCNPs的光学特性，重点综述了NIR光诱导的UCNPs-Au NPs（纳米壳、纳米棒、纳米团簇）复合纳米体系在癌症光热治疗领域的最新研究进展，并对其实现诊疗一体化的未来进行了展望。
关键词：近红外；光热治疗；荧光成像；上转换纳米颗粒；金纳米颗粒
中图分类号：Q631                              文献标志码：A                        DOI：10.3969/j.issn.1007-7146.2023.04.002

Abstract: Near-infrared (NIR) light-induced photothermal therapy (PTT) has become a new method for precise tumor treatment due to its non-invasive, low toxicity, and targeted treatment.  Gold nanoparticles have become an ideal photothermal agents due to its unique surface plasmon resonance (SPR), efficient photothermal conversion efficiency, low biological toxicity and good photostability. High quality imaging technology is a reliable and powerful tool for achieving effective photothermal therapy, especially multimodal imaging technology, which has excellent performance compared to a single imaging method, providing the possibility for more comprehensive and accurate tumor imaging, thereby significantly improving the potential of non-invasive medical treatment. Owing to their rich 4f electronic structure, NIR light excited rare-earth doped upconversion nanoparticles (UCNPs) exhibit multifunctional properties such as magnetism, fluorescence, X-ray attenuation, and radiation, making them an important application prospect in multimodal imaging as contrast agents. Therefore, constructing NIR-induced Au NPs/UCNPs composite nanosystems for multimodal imaging-guided photothermal therapy is expected to become a new strategy for cancer diagnosis and treatment. In this paper, we briefly introduced the optical properties of Au and UCNPs.  In addition, this paper reviewed the latest research progress of PTT research on NIR induced UCNPs Au (nanoshell, nanorod, nanoclusters) composite nano system under the guidance of visual fluorescence imaging. The future prospects for achieving integrated diagnosis and treatment are presented, providing new ideas for its further research, development, and clinical application.
Key words: near-infrared; photothermal therapy; fluorescence imaging; upconversion nanoparticles; Au NPs
（Acta Laser Biology Sinica, 2023, 32(4): 297-303）