本文旨在研究基于表面增强拉曼光谱（SERS）技术检测尿液中血小板衍生生长因子（PDGFBB）从而对冠状动脉堵塞程度进行快速无损诊断的方法是否同样适用于长期服用药物（阿司匹林、瑞舒伐他汀或硫酸氢氯吡格雷）的冠心病患者或行经皮冠状动脉介入手术（PCI术）后病人的冠状动脉堵塞程度检测。首先基于该方法对13例长期服用药物（阿司匹林、瑞舒伐他汀或硫酸氢氯吡格雷）的冠心病患者和13例行PCI术后病人的尿液样本进行检测，发现其SERS光谱中均无PDGF-BB位于1 509 cm^-1的拉曼特征峰。然后进一步分析PDGFBB水溶液与三种药物的SERS光谱，也均未发现1 509 cm^-1的拉曼特征峰。结果表明，这三种药物均对PDGF-BB的SERS信号产生了影响，可见该方法并不适用于长期服用药物的冠心病患者或行PCI病人术后的冠状动脉堵塞程度的检测。

A rapid and noninvasive method based on surfaceenhanced Raman spectroscopy （SERS) was developed to diagnose congestion degree of coronary arteries prospectively by detecting plateletderived growth factorBB （PDGF-BB) in urine samples in our previous research. This work was to investigate whether the developed method could be applied to the patients on longterm medication including aspirin, rosuvastatin, clopidogrel bisulfate,  and postPCI patients for the  diagnosis of congestion degree of coronary arteries. Firstly, urine samples from 13 patients on longterm medication  and from 13 postPCI patients were measured based on the developed method. It was found that there was no Raman peak at 1 509 cm^-1 attributed to PDGFBB in these SERS spectra. In addition, further investigation of SERS spectra of aqueous solutions of PDGF-BB mixed with three kinds of drugs was conducted. There was no Raman peak at 1 509 cm^-1 in these three spectra as well. It turned out that these drugs had impact on the SERS signal of PDGFBB, and this method was not suitable for the detection of congestion degree of coronary arteries for patients on longterm medication and postPCI patients.