摘 要：糖脂代谢紊乱是2型糖尿病（T2DM）、肥胖症等代谢性疾病的核心病理基础，而表观遗传调控因子溴结构域蛋白4（BRD4）在其中扮演着关键角色。本文系统阐述了BRD4通过表观遗传调控、信号通路交互及器官特异性网络调控糖脂代谢的分子机制，以及其在代谢疾病中的病理作用与治疗潜力。
关键词：溴结构域蛋白4；糖代谢；脂代谢；表观遗传调控；胰岛素信号通路
中图分类号：Q591.4；Q591.5 文献标志码：A DOI：10.3969/j.issn.1007-7146.2026.04.003
Abstract: Disordered glycolipid metabolism is the core pathological basis of metabolic diseases such as type 2 diabetes mellitus (T2DM) and obesity, and the epigenetic regulatory factor bromodomain-containing protein 4 (BRD4) plays a key role in this process. This article systematically reviews the molecular mechanisms by which BRD4 regulates glycolipid metabolism through epigenetic regulation, signaling pathway crosstalk, and organ-specific regulatory networks, as well as its pathological role and therapeutic potential in metabolic diseases.
Keywords: BRD4; glucose metabolism; lipid metabolism; epigenetic regulation; insulin signaling pathway
（Acta Laser Biology Sinica, 2026, 35(4): 310-318）
Abstract: Disordered glycolipid metabolism is the core pathological basis of metabolic diseases such as type 2 diabetes mellitus (T2DM) and obesity, and the epigenetic regulatory factor bromodomain-containing protein 4 (BRD4) plays a key role in this process. This article systematically reviews the molecular mechanisms by which BRD4 regulates glycolipid metabolism through epigenetic regulation, signaling pathway crosstalk, and organ-specific regulatory networks, as well as its pathological role and therapeutic potential in metabolic diseases.
Keywords: BRD4; glucose metabolism; lipid metabolism; epigenetic regulation; insulin signaling pathway
（Acta Laser Biology Sinica, 2026, 35(4): 310-318）
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