（1. 华南师范大学光电科学与工程学院，生物光子学研究院，激光生命科学教育部重点实验室，广州 510631；2. 华南师范大学光电科学与工程学院，生物光子学研究院，广东省激光生命科学重点实验室，广州 510631)
摘 要：阿尔茨海默病（AD）和帕金森病（PD）等神经系统疾病严重威胁人类健康，目前仍缺乏有效治疗策略。近年来，调控异常伽马振荡（特别是40 Hz）的研究为干预这些疾病提供了新思路。本文综述了40 Hz感官刺激（光和声音）在改善AD、PD、癫痫、抑郁症（MDD）、自闭症等疾病病理及认知功能方面的研究进展，探讨其促进神经同步的作用原理及潜在机制，并评估其作为非侵入性治疗手段的临床应用价值。同时，分析了当前研究在刺激参数优化、个体差异影响及安全性评估方面的挑战，并展望深入机制研究与大规模临床验证的必要性。总体而言，40 Hz感官刺激具有治疗神经系统疾病的潜力，为精准医学和神经调控技术的发展提供了重要科学依据。
关键词：40 Hz光和声音感官刺激；伽马振荡；神经同步；神经退行性疾病；非侵入性治疗
中图分类号：Q631                   文献标志码：A                        DOI：10.3969/j.issn.1007-7146.2026.02.008

Abstract: Neurological disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) pose serious threats to human health due to the lack of effective treatments. Recent studies on modulating abnormal gamma oscillations, particularly at 40 Hz, offer new therapeutic strategies. This review summarizes the advances in 40 Hz sensory stimulation involving light and sound for improving neuropathology and cognitive function in AD, PD, major depressive disorder (MDD), and epilepsy, explores the mechanisms underlying neural synchronization, and evaluates its potential as a non-invasive treatment. Challenges such as optimizing stimulation parameters, addressing individual variability, and ensuring safety are also discussed, along with the necessity for further mechanistic studies and large-scale clinical validation. In conclusion, 40 Hz sensory stimulation shows promise for treating neurological disorders and provides a foundation for advancements in precision medicine and neuromodulation technology.
Key words: 40 Hz light and sound sensory stimulation; gamma oscillations; neural synchronization; neurodegenerative diseases; non-invasive treatment
（Acta Laser Biology Sinica, 2026, 35(2): 168-178）