摘 要：骨缺损是骨科领域急需解决的严重医学问题，其成因涵盖创伤性骨折、先天性骨发育异常等多种情况，通常无法通过人体自身的修复来愈合。因此，探索高效加速骨缺损修复的策略，始终是骨科研究的核心目标之一。组织工程为骨缺损修复提供了关键的物理支撑与微环境，已成为骨缺损修复的重要方向。而如何进一步提升支架介导的骨再生效率、优化修复效果，更是当前该领域的研究热点。研究表明，光生物调节作用（PBM）作为一种非侵入性物理治疗手段，可以通过生物刺激作用显著促进骨组织再生。基于此，本文将系统分析PBM的生物刺激机制，结合其在临床骨缺损治疗中的应用实践，阐述PBM的优势及临床应用前景，以期为骨缺损的临床治疗提供新的思路与技术参考。
关键词：光生物调节作用；组织工程；骨缺损；作用机制；临床应用
中图分类号：R318.51                文献标志码：A     DOI：10.3969/j.issn.1007-7146.2026.02.007

Abstract: Bone defects are a serious medical problem in the field of orthopedics that urgently needs to be addressed. Their causes include traumatic fractures, congenital bone developmental abnormalities, and various other conditions, and they usually cannot heal through the body’s own repair mechanisms. Therefore, exploring strategies to efficiently accelerate the repair of bone defects has always been one of the core goals of orthopedic research. Tissue engineering provides critical physical support and a microenvironment for bone defect repair and has become an important direction in bone defect treatment. How to further enhance scaffold-mediated bone regeneration efficiency and optimize repair outcomes is currently a research hotspot in this field. Studies have shown that photobiomodulation (PBM), as a non-invasive physical therapy method, can significantly promote bone tissue regeneration through biological stimulation. Based on this, this paper will systematically analyze the biostimulation mechanism of photobiomodulation and its application practice in the treatment of clinical bone defects, and expound the advantages and clinical application prospects of photobiomodulation, in order to provide new ideas and technical references for the clinical treatment of bone defects.
Key words: photobiomodulation; tissue engineering; bone defects; mechanism of action; clinical application
（Acta Laser Biology Sinica, 2026, 35(2): 162-167）