摘　要：为了探究哺乳动物病毒共受体间的共性特征，本研究基于ViralReceptor数据库中收集的哺乳动物病毒-受体相互作用关系，共收集277对病毒共受体组合，从结构、功能、进化和组织表达等方面对这些病毒共受体进行系统分析，并与来源于不同哺乳动物的病毒受体组合以及随机挑选的人类蛋白组合进行比较。结果显示，哺乳动物病毒共受体相较于其他蛋白组合，彼此间有更高的功能相似性，在宿主蛋白相互作用网络中相互作用的比例更高，在人体常见组织中的共表达水平更高。研究表明，哺乳动物病毒共受体具有功能、表达和互作等共性特征。期望此结果能为病毒受体的发现和鉴定等研究提供参考。

关键词：哺乳动物病毒；生物信息学；病毒共受体；病毒受体；人类蛋白组合

中图分类号：Q939.4                             文献标志码：A                  DOI：10.3969/j.issn.1007-7146.2023.06.006

Abstract: To investigate the common characteristics of mammalian virus co-receptors, this study collected 277 pairs of viral co-receptor combinations based on the data from ViralReceptor database. We investigated the structural, functional, evolutionary and tissue expression characteristics of mammalian virus co-receptors and compared them with combinations of viral receptors derived from different mammalian viruses, as well as randomly selected human proteins. The results showed that in comparison to other protein pairs, mammalian virus co-receptors exhibited higher functional similarity, higher ratio of interaction in the host protein interaction network, and higher co-expression levels in common human tissues. This study demonstrates that mammalian virus co-receptors share common features such as functionality, expression, and interaction, with the expectation that these findings will provide a reference for the discovery and identification of virus receptors.

Key words: mammalian virus; bioinformatic; virus co-receptor; virus receptor; human protein combination

（Acta Laser Biology Sinica, 2023, 32(6): 537-547）