摘　要：鱼类细菌性病害对发展鱼类养殖业构成了严重的威胁，而抗生素的滥用和病原菌耐药性的出现对鱼类养殖产量、水产品质量和养殖环境造成了严重的影响。为了推动鱼类健康养殖产业的发展，亟待创新研究鱼类病害的绿色防控技术。噬菌体作为一种天然、无残留的细菌杀手，具有特异性强、裂解效率高等特点，利用噬菌体治疗鱼类细菌性病害将是一种重要的技术途径。本文综述了噬菌体的重要资源挖掘、鱼类细菌性病害防控中的作用机制及其应用前景，并提出了在鱼类健康养殖领域加快研究噬菌体治疗技术的措施，对鱼类的健康养殖具有重要意义。

关键词：鱼类养殖；噬菌体治疗；细菌性病害；细菌杀手；绿色防控技术

中图分类号：Q93                             文献标志码：A                   DOI：10.3969/j.issn.1007-7146.2023.06.004

 

Abstract: Bacterial diseases of fish pose a serious threat to the development of fish breeding industry, and the abuse of antibiotics and the emergence of drug resistance of pathogenic bacteria have a serious impact on the yield of fish breeding, the quality of aquatic products and the breeding environment. In order to promote the development of healthy fish breeding industry, it is urgent to innovate the green prevention and control technology of fish diseases. As a natural and non-residual bacterial killer, phage has the characteristics of strong specificity and high lysis efficiency. Using phage to treat bacterial diseases of fish will be an important technical approach. This paper reviews the important resource mining of phages, the mechanism of action in the prevention and control of bacterial diseases in fish and its application prospects, and puts forward measures to speed up the research of phage treatment technology in the field of healthy aquaculture of fish, which is of great significance for healthy aquaculture of fish.

Key words: fish farming; phage therapy; bacterial diseases; bacterial killer; green prevention and control technology

（Acta Laser Biology Sinica, 2023, 32(6): 517-524）