摘　要：肿瘤微环境呈现出一个错综复杂的生态系统，包括肿瘤细胞、非癌细胞、细胞外基质以及微生物群落等多种要素。微生物在肿瘤内广泛分布，其在空间分布上呈现出显著的特异性。这些微生物的组成成分与功能状态在肿瘤的发生和进展中发挥着至关重要的作用。本文深入阐明了肿瘤微环境内微生物菌群的特征，并探索其对肿瘤发生发展的影响机制，以期为肿瘤的诊断和治疗提供全新的策略和视角。
关键词：肿瘤；肿瘤微环境；微生物；微生物群落；肿瘤诊疗
中图分类号：R73-36+2                          文献标志码：A                    DOI：10.3969/j.issn.1007-7146.2023.05.001

Abstract: The tumor microenvironment comprises a multifaceted ecosystem encompassing a dynamic interplay between malignant cells, non-neoplastic counterparts, extracellular matrix constituents, and intricate microbial communities. In particular, microorganisms have established a pervasive presence within tumor masses, exhibiting a marked predilection for distinct spatial niches. The intricate amalgamation of their composition and multifaceted functional profiles assumes a commanding role in orchestrating the intricate ballet of tumor genesis and advancement. In this comprehensive review, we endeavor to illuminate the intricacies of intratumoral microbiota, unraveling the intricate molecular mechanisms that underpin its profound influence on the initiation and relentless progression of neoplastic growth. By doing so, we unveil a panorama of novel perspectives that hold promise in revolutionizing both diagnostic paradigms and therapeutic modalities for tumors.
Key words: tumor; tumor microenvironment; microbe; microbial community; oncology treatment
（Acta Laser Biology Sinica, 2023, 32(5): 385-392）