摘　要：激光散斑对比成像（LSCI）是一种以宽视场方式监测血流速度的非扫描光学成像技术。LSCI技术具有高时间-空间分辨率、快速实时成像、非接触式、仪器结构简单、无需造影剂等优势。本文简要介绍了LSCI的基本原理，概述了反射式LSCI和透射式LSCI两种结构，综述了LSCI在皮肤血流、大脑皮层和视网膜血流等生物医学应用中的最新研究进展，并对其发展前景做了进一步展望，为血流监测提供理论依据和实践指导。
关键词：激光散斑对比成像；组织灌注；血流速度；血流监测；血流微循环
中图分类号：R318；TN249                       文献标志码：A                  DOI：10.3969/j.issn.1007-7146.2023.01.002

Abstract: Laser speckle contrast imaging (LSCI) is a non-scanning optical imaging technique with wide field of view for monitoring blood flow velocity. LSCI technology has advantages of high temporal-spatial resolution, fast real-time imaging, non-contact, simple structure, and no contrast agent. Here we briefly introduced the basic principles of LSCI, structures of reflective-detected LSCI and transmissive-detected LSCI. In addition, this paper reviewed the latest research progress of LSCI in biomedical applications such as skin blood flow, cerebral cortex and retinal blood flow, and makes further prospects for its development, provide theoretical basis and practical guidance for blood flow monitoring.
Key words: laser speckle contrast imaging; tissue perfusion; blood flow velocity; blood flow monitoring; blood microcirculation
（Acta Laser Biology Sinica, 2023, 32(1): 008-014）