摘　要：聚酮化合物（PKs）作为一大类次级代谢产物，有着重要的生物活性和潜在的应用价值。链霉菌具有合成多种聚酮化合物的潜力，但野生型菌株合成聚酮化合物的产量难以满足工业化生产的需求。贮藏脂质的降解能为聚酮化合物生物合成提供大量的酰基CoA前体，因此，控制好脂肪酸与聚酮化合物生物合成通量，有利于促进目标聚酮化合物的合成。本文综述了强化脂肪酸β-氧化途径提高聚酮化合物产量的研究进展，为利用β-氧化途径促进聚酮化合物生物合成提供了新的研究策略。
关键词：聚酮化合物；脂肪酸代谢；β-氧化；生物合成；链霉菌
中图分类号：Q936                                文献标志码：A                    DOI：10.3969/j.issn.1007-7146.2023.01.001

Abstract: As a large class of secondary metabolites, PKs have important biological activity and economic value. Streptomyces has the potential to synthesize a variety of PKs, whereas the yield of PKs synthesized by wild-type strains is difficult to meet the needs of industrial production. The degradation of storage lipids can provide a large number of acyl-CoA precursors for the biosynthesis of PKs. Therefore, controlling the balance of the biosynthetic flux of fatty acids and PKs is conducive to improving the production of the target PKs. This paper briefly reviews on improving the production of PKs by strengthening the fatty acids β-oxidation pathway, and prospects prospective research ideas on improving the biosynthesis of PKs by engineering the β-oxidation pathway.
Key words: polyketides; fatty acid metabolism; β-oxidation; biosynthesis; Streptomyces
（Acta Laser Biology Sinica, 2023, 32(1): 001-007）