摘  要：黄芩苷（baicalin）是由黄芩（Scutellaria baicalensis Georgi）根部分离而来的黄酮类物质，为黄芩的主要活性成分。黄芩苷药理作用广泛，具有良好的抗炎效果，其主要机制包括调节肠道菌群、抑制核因子κB（NF-κB）核转位、增加相关microRNA的表达、抑制自噬、调节Treg/Th17平衡等。现综述黄芩苷抗炎症作用机制的最新研究进展，为其深入研究及在临床上的应用提供依据。
关键词：黄芩苷；炎症；肠道菌群；NF-κB；miRNA
中图分类号：R97                             文献标志码：A DOI：10.3969/j.issn.1007-7146.2021.05.003

Abstract: Baicalin, a kind of flavonoid substance derived from the root part of Scutellaria baicalensis Georgi, which is the main active ingredient of the plant. The pharmacological effect of baicalin is extensive and it shows great potential in its anti-inflammatory effect, and its main mechanisms include regulating intestinal flora, inhibiting NF-κB nuclear transposing, increasing the expression of related microRNA, inhibiting autophagy, and regulating Treg/Th17 balance. This article reviewed the research progress of baicalin on the anti-inflammatory mechanism at home and abroad, which provides a basis for its clinical application and further study.
Key words: baicalin; inflammation; intestinal flora; NF-κB; miRNA
（Acta Laser Biology Sinica, 2021, 30(5): 400-405）