摘　要：一氧化氮（NO）气体治疗是一种新兴的癌症治疗方式，具有毒性小、便于新陈代谢的优点，可以通过破坏和抑制DNA的合成和修复、损伤线粒体细胞器等抑制癌细胞的生长。但NO气体分子的半衰期短、难以控制的特点也限制了其在肿瘤治疗领域的发展。因此，构建可控释放NO的纳米体系并结合其他治疗方案的协同抗癌机制非常重要。本文主要介绍了NO气体治疗结合放射治疗、超声治疗、光热疗法、活性氧治疗、化学治疗的协同抗癌纳米体系的构建及抗肿瘤效果，讨论了NO气体治疗和传统癌症治疗方式结合的多模式治疗在肿瘤治疗领域的潜在应用。
关键词：一氧化氮；纳米体系；协同抗癌；多模式治疗；抗癌机制
中图分类号：R73-34；R730.5　　　　　文献标志码：ADOI：10.3969/j.issn.1007-7146.2021.05.002

Abstract: Nitric oxide (NO) gas therapy is a new cancer treatment method, which has the advantages of low toxicity and convenient metabolism. It can inhibit the growth of cancer cells by destroying and inhibiting DNA synthesis and repair, damaging mitochondrial organelles, etc., whereas the short half-life and uncontrollable of NO gas molecules also limit its development in the field of tumor therapy. Therefore, NO-releasing nanosystem that combine with other existent cancer treatments for synergistic anti-cancer therapy is very important. This article mainly introduces the construction and its anticancer mechanism of the multi-modal treatment of NO gas therapy combined with traditional treatment methods such as radiotherapy, ultrasound therapy, photothermal therapy, reactive oxygen species stimulation, chemotherapy. The potential application of combining NO and traditional cancer treatment methods in the field of tumor treatment are highlighted.
Key words: nitro oxide; nanosystem; synergistic anti-cancer; multi-modal treatment; anticancer mechanism
（Acta Laser Biology Sinica, 2021, 30(5): 392-399）