摘  要：长链非编码RNA（lncRNA）是指长度大于200 bp的非编码RNA。在肺癌发生发展的过程中有大量lncRNA的表达发生异常变化，这些lncRNA主要通过调控肺癌细胞的增殖、凋亡、迁移、自噬等方面影响肺癌的病理生理过程。近些年，以lncRNA为靶点的中药抗肺癌研究逐渐增多，本文主要就肺癌中异常表达的lncRNA及其作用机制进行了综述，并概述了以lncRNA为靶点的抗肺癌中药治疗进展，以期为肺癌的治疗和研究提供新方法和新思路。
关键词：lncRNA；肺癌；中药；诊断；治疗
中图分类号：R734.2　　　　　　文献标志码：A 　　　　　　DOI: 10.3969/j.issn.1007-7146.2020.06.002

Abstract: Long non-coding RNA (lncRNA) are a group of non-coding RNA that consist of more than 200 nucleotides. A review of the literature indicates that a large amount of lncRNA expression changes abnormally during the development of lung cancer. These lncRNA mainly affect the pathophysiological process of lung cancer by regulating the proliferation, apoptosis, migration, and autophagy of lung cancer cells. Recently, research on anti-lung cancer of traditional Chinese medicine targeting lncRNA is increasing. This article mainly reviews the abnormal expression of lncRNA and its mechanism of lncRNA action and summarizes the research progress of lung cancer treatment through traditional Chinese medicine with lncRNA as therapeutic target, be expecting to provide new methods and new ideas for the treatment and research of lung cancer.
Key words: lncRNA; lung cancer; Chinese medicine; diagnosis; therapy