摘  要：放射治疗是临床肿瘤治疗中一种广泛使用的物理疗法，然而，辐射引起的肿瘤转移往往会导致治疗失败。肿瘤转移和肿瘤血管生成密切相关，抗血管生成药物联合放疗可显著改善临床肿瘤患者的预后，因此，放疗相关肿瘤血管生成的研究对于临床肿瘤放射治疗意义重大。本综述目的在于总结放射治疗相关肿瘤血管生成方面的最新研究进展，为优化放射治疗临床方案和研发肿瘤血管生成的靶向药物提供参考。
关键词：放射治疗；肿瘤转移；肿瘤血管生成；抗血管生成药物；联合放疗
中图分类号：R81；TL99　　　　　  文献标志码：A　　　　　  DOI: 10.3969/j.issn.1007-7146.2020.06.001

Abstract: Radiotherapy is one of the conventional treatments of tumor. However, radiation-induced metastasis usually results in the poor clinical outcome of radiotherapy. Tumor angiogenesis is tightly related to its metastasis and the combined administration of anti-angiogenetic drugs with radiotherapy effectively improves the prognosis of tumor radiotherapy, therefore, studies on radiation-related angiogenesis are of practical significance. The purpose of this review is to summarize the recent research progress on tumor angiogenesis related to radiotherapy and to provide a considerable reference for developing medicine targeting on angiogenesis and improving the clinical outcome of radiotherapy.
Key words: radiotherapy; tumor metastasis; tumor angiogenesis; anti-angiogenetic drugs; combined radiotherapy