本文通过溶胶凝胶法制备了BiFeO3@TiO₂复合纳米颗粒，利用透射电镜（TEM）、X射线衍射（XRD）、荧光发光光谱等对纳米颗粒进行表征。研究采用Cell Counting Kit8（CCK8）法分别检测了在暗室条件、光照条件以及不同强度的弱稳恒磁场作用下，用终值质量浓度为50 μg/mL纳米颗粒处理HL60细胞活性，试验结果表明：在暗室条件下，药物质量浓度为50 μg/mL,与HL60细胞共同孵育12 h后，BiFeO₃@TiO₂复合纳米颗粒随着TiO₂外壳厚度增加，细胞的暗室相对存活率从78%增加到85%；在光照条件下，有弱稳恒磁场作用的BiFeO₃与TiO₂质量比为12的BiFeO₃@TiO₂复合纳米颗粒对HL60细胞的PDT灭活效率最高达到78%，弱稳恒磁场环境增强了对HL60细胞的PDT灭活效率，这为对弱稳恒磁场环境下的光动力疗法治疗白血病肿瘤细胞的临床应用提供了参考。

In this paper, BiFeO₃@TiO₂ composites nanoparticles were synthesized by solgol method. The nanoparticles were characterized by transmission electron microscope (TEM), Xray diffraction (XRD), fluorescence emission spectrum etc. The Cell Counting Kit8 (CCK8) method was used to detect the activity of HL60 cells treated with a final concentration of 50 μg/mL nanoparticles under the action of weak stable magnetic field with different strengths in dark room and light conditions. The experimental results showed that the viability of HL60 cells treated with BiFeO₃@TiO₂ composites nanoparticles for 12 hours at a concentration of 50 μg/mL increased from 78% to 85%, with the increment of TiO₂ shell thickness in the darkroom condition. However, cell groups treated by BiFeO₃@TiO₂ composites nanoparticles with a mass ratio of BiFeO₃ to TiO₂of 1∶2 showed the highest cell inactivated efficiency of 78% under light exposure. The weak stable magnetic field enhanced the PDT inactivation efficiency of HL60 cells.Therefore,it provides a reference for the clinical application of photodynamic therapy in the treatment of tumor cells under weak stable magenetic field.