利用金属有机框架材料ZIF-8包裹二硫化钼（MoS₂）纳米片和阿霉素（DOX）构建一种可通过酸性pH和近红外（NIR）光双触发的肿瘤化学/光热协同治疗体系。首先，通过水热反应和超声处理制备粒径为~100 nm、厚度为0.31.4 nm的MoS₂纳米片。然后，通过一步法将可酸降解的金属有机框架ZIF8包裹在所制备的MoS₂纳米片上，并同时装载抗肿瘤药物DOX，形成装载DOX的ZIF-8包裹MoS₂纳米复合物（DOX/MoS₂@ZIF-8）。将该纳米复合物应用到肿瘤细胞的化学/光热协同治疗：当处于酸性条件（例如：溶酶体中pH大约为5）和NIR激光（780 nm，2.1 W/cm²）照射的情况下，DOX/MoS₂@ZIF8纳米复合物上包裹的ZIF-8金属有机框架会发生酸降解，释放出所包裹的DOX，细胞质中的DOX可以进入细胞核中诱导细胞凋亡；同时，MoS₂纳米片能够将光能转换为热能，光致高温同样能诱导细胞凋亡，因此，化学/光热协同肿瘤治疗得以实现。细胞存活率试验证明：该DOX/MoS₂@ZIF-8纳米复合物在SMMC-7721细胞上表现出良好的化学/光热协同治疗作用，能够对肿瘤细胞进行高效地杀伤。

Here, we report a novel metal-organic framework ZIF-8based nanocomposite with encapsulated molybdenum disulfide(MoS₂)nanosheets and doxorubicin(DOX)for pH- and NIR-triggered synergistic chemo/photothermal treatment of cancer cells. First, MoS₂ nanosheets, which have uniform size of ~100 nm and topological height of 0.3~1.4 nm, are synthesized by hydrothermal reaction and ultrasonic treatment. Subsequently,an aciddegradable metalorganic framework ZIF-8 is employed to synchronously encapsulate MoS₂ nanosheets and anticancer drug DOX to obtain DOX loaded ZIF-8 coated MoS₂ (DOX/MoS₂@ZIF-8)nanocomposites by onestep method. The nanocomposites are used for chemo/photothermal synergistic treatment of cancer cells: under acid conditions (e.g. pH 5.0 in a lysosome)and NIR laser irradiation (780 nm, 2.1 W/cm²), the ZIF-8 of the DOX/MoS₂@ZIF-8 nanocomposites can be degraded, resulting in the release of encapsulated DOX, the cytosolic DOX can enter the nucleus to induce apoptosis. Meanwhile, the MoS₂ nanosheets can effectively convert NIR laser light energy into heat energy, the photoinduced hyperthermia can also induce apoptosis. Thus, chemo/photothermal synergistic cancer therapy is realized. Cell viability assays show that this DOX/MoS₂@ZIF-8 nanocomposites have an excellent chemo/photothermal synergistic treatment effect on SMMC7721 cells, which can kill the tumor cells efficiently.