5-氨基酮戊酸（ALA）是体表光动力疗法的一个重要前体药物，通过代谢产物原卟啉Ⅸ（PpⅨ）介导发挥光敏作用。ALA制剂的研发和优化促生了一系列产品和技术，不仅推动了体表光动力疗法的应用，而且ALA介导的PpⅨ荧光还可用于肿瘤的荧光可视化和辅助手术。本文将对光动力诊疗中ALA及其酯类衍生物和PpⅨ的研究进展作一个系统介绍。

5-Aminolevulinic acid (ALA) is an important prodrug in topical photodynamic therapy (PDT). Its photosensitization is mediated through protoporphyrin Ⅸ (PpⅨ). The ALArelated drug development and application optimization promote a series of products and techniques that expanded the clinical applications of topical PDT. PpⅨ fluorescence visualization not only plays an important role in topical PDT, it is also useful in fluorescenceguided surgery for bladder cancer and gliomas. This review will provide an overview on some progress in ALA, ALA esters and PpⅨ applications.