研究MICA等位基因多态性与海南人群HBV感染易感性之间的关联性。采用PCRSSP和PCRSBT方法对样本MICA等位基因的多态性进行检测。HBV感染患者中共检出10 种MICA 等位基因和5种MICASTR等位基因，和对照组相比较，MICA*010、MICAA5等位基因可能对HBV感染易感(MICA*010：OR=3.88，95%CI：2.19〖KG-*3〗~6.85，P=0.000；MICAA5：OR=1.27，95%CI：0.92〖KG-*3〗~1.77，P=0.0068)。MICA*008/045基因型可能对HBV感染不易感，MICA*010/010 纯合子基因型可能对HBV易感(MICA* 008/045：OR=0.09，95%CI：0.01〖KG-*3〗~1.74，P=0.0071；MICA*010/010：OR=4.41，95%CI：1.26〖KG-*3〗~15.46，P=0.0106)。MICA等位基因多态性与海南人群HBV感染的易感性间存在关联性。

To study the association between MICA allelic polymorphism and susceptibility to HBV infection in Hainan population. Polymorphism of MICA alleles in samples was detected by PCRSSP and PCR method. A total of 10 MICA alleles and 5 MICASTR alleles were detected in HBV infected patients. Compared with the control group, MICA 010 and MICAA5 allele may be susceptible to HBV infection.For MICA*010:OR=3.88, 95%CI:2.19〖KG-*3〗~6.85, P=0.000, MICAA5: OR=1.27, 95%CI: 0.92〖KG-*3〗~1.77, P=0.0068. MICA*008 / 045 genotype may not be susceptible to HBV infection, and MICA 010/010 homozygous genotype may be susceptible to HBV infection.For MICA* 008/045: OR=0.09, 95%CI: 0.01〖KG-*3〗~1.74, P=0.0071; For MICA*010/010:OR=4.41, 95%CI: 1.26〖KG-*3〗~15.46, P=0.0106. MICA allelic polymorphism was associated with susceptibility to HBV infection in Hainan population.