本中心回顾性研究咖啡斑患者84例，随机给予Q开关532 nm和755 nm激光治疗，观察临床效果。结果显示，Q开关532 nm激光治疗36例，痊愈10例（27.8%），显效10例（27.8%），有效8例（22.2%），无效8例（22.2%）；Q开关755 nm激光治疗48例，痊愈14例（29.2%），显效13例（27.1%），有效11例（22.9%），无效10例（20.8%），84例患者总有效率78.6%。术后半年随访，色素沉着9例，色素减退3例，复发9例。Q开关激光治疗形状不规则的咖啡斑有效率为79.5%，治疗形状规则的咖啡斑有效率为52.5%，两组治疗的有效率差异有统计学意义（P＜0.05），Q开关532 nm激光和Q开关755 nm激光对咖啡斑的治疗效果无显著的统计学差异（P＞0.05）。以上结果表明，Q开关532 nm激光和Q开关755 nm激光对咖啡斑有明确的治疗效果，且外形不规则的咖啡斑治疗效果好。

Eighty four patients with cafeaulait were treated with Qswitched 532 nm or 755 nm laser randomly by our center. The clinical efficacy was assessed. 36 patients were treated with Qswitched 532 nm laser, 10 patients were completely cured (27.8%), 10 patients were significantly improved (27.8%), 8 improved (22.2%) and 8 invalid (22.2%); 48 patients were treated with Qswitched 755 nm laser, 14 patients were cured completely (29.2%), 13 patients were significantly improved (27.1%), 11 improved (22.9%) and 10 invalid (20.8%). Of the 84 patients, total effective rate is 78.6%. After 6 months of followup, 9 patients appeared pigmentation, 3 patients appeared hypopigmentation and 9 recrudesced. The effective rate of cafeaulait with regular shape is 52.5%, and irregular shape is 79.5%, there was a significant difference between two teams (P＜0.05). There was no significant difference in efficacy between Qswitched 532 nm and 755 nm laser (P＞0.05). The above results showed  Qswitched 532 nm and 755 nm laser were effective agents for treatment of  cafeaulait.，and the efficacy of Qswitched laser on cafeaulait with regular shape is better than those with irregular shape．