本研究主要是探讨腹腔镜胆囊切除术（LC）联合胆总管探查（LCBDE）联合一期缝合（PS）治疗胆囊结石合并胆总管结石的临床效果。选取我院（2014年1月至2016年1月）手术治疗的85例胆囊结石合并胆总管结石患者进行回顾性分析，根据手术方法分为A组41例（LC+LCBDE+PS治疗）、B组44例采用内镜逆行性胆管造影/内镜下括约肌切开取石术（ERCP/EST）联合LC治疗，对比两组患者的手术效果。A组和B组患者的手术时间差异无统计学意义（P<0.05）；A组患者的出血量、住院时间、手术费用均低于B组患者，差异具有统计学意义（P<0.05）；术后1天，两组患者的血清IL6、TNFα、CRP、ALT、AST、TBIL较本组术前均显著的提高（P<0.05）；术后3天，两组患者的血清IL6、TNFα、CRP较本组术前显著的提高（P<0.05）；手术后，A组患者手术并发症率12.20%（5/41）与B组的22.73%（10/44）比较，差异无统计学意义（P>0.05）。结果表明，LC+LCBDE+PS治疗胆囊结石合并胆总管结石效果与ERCP/EST联合LC效果相当，但是具有术后恢复较快、费用更低的特点。

The objective of this study is to determine  the clinical effects of laparoscopic cholecystectomy (LC) combined with common bile duct exploration (LCBDE) and with primary suture (PS) respectively in the treatment of cholecystolithiasis and choledocholithiasis. In our hospital  the surgical treatment of 85 cases of cholecystolithiasis with common bile duct stones were retrospectively analyzed from January 2014 to January 2016, according to the operation method, were divided into 41 cases of group A (LC+LCBDE+PS treatment), group B of 44 cases by endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy (ERCP/EST) combined with LC therapy. The operation effects of the two groups were compared. No statistically significant differences in operative time of A group and B group (P<0.05); bleeding patients in the A group, hospitalization time, operation cost are lower than those of B group, the differences were statistically significant (P<0.05); One days after operation, two groups of patients with serum IL6, TNFα, CRP, ALT, alpha, AST TBIL  were significantly increased compared with the group before operation(P<0.05), 3 days after operation, two groups of patients with serum IL6, TNF alpha, CRP increased significantly compared with the group before surgery  (P<0.05); after the operation, the rate of complications in 12.20% patients in group A (5/41) and  group B had  no significant difference (10/44) compared to 22.73%(P>0.05). It is found that the effect of LC+LCBDE+PS on cholecystolithiasis combined with common bile duct stones is similar to that of ERCP/EST combined with LC, but it has the characteristics of quicker recovery and lower cost.