巨噬细胞极化在骨修复中起着非常重要的作用。骨修复材料在植入体内后，会引起巨噬细胞的响应，使其向M1/M2极化，从而影响材料的成骨效果。本文制备了掺锶量分别为0%，5%，10%和15%摩尔百分比的锶掺杂微纳米生物活性玻璃（SrMNBG），并研究了不同掺锶量的SrMNBG对巨噬细胞极化的影响；随后，在此基础上研究了不同掺锶量SrMNBG调控的巨噬细胞分泌成分对小鼠骨髓间充质干细胞（mMSCs）向成骨分化的影响；最后，通过体内原位骨缺损修复实验验证了不同掺锶量SrMNBG对巨噬细胞极化的调控作用及其体内成骨作用。体外实验结果显示，掺锶量为5%，10%和15%的SrMNBG较掺锶量为0%的SrMNBG更能促进巨噬细胞向M2极化，其中10%掺锶量的SrMNBG具有最强的促巨噬细胞M2极化作用，且10%掺锶量的SrMNBG调控的巨噬细胞分泌成分更有利于成骨。体内实验结果表明，不同掺锶量的SrMNBG植入到体内后，10%掺锶量的SrMNBG周围有更多的M2巨噬细胞浸润，且表现出更好的骨修复效果，与体外实验结果相一致。因此，SrMNBG有望作为一种富有前景的免疫调控材料应用于骨修复。

Macrophage polarization plays an important role in bone repair. Once being implanted in the body, bone repair materials will trigger response of macrophage, making it switch to M1/M2 phenotype, thus affect the osteogenic effect of the material. In this work, Strontiumsubstituted micro/nano bioactive glasses （SrMNBG）with 0, 5%, 10% and 15% molar percent of strontium element were prepared, and the effect of SrMNBG on macrophage polarization was studied. Subsequently, the effects of SrMNBG with different strontium incorporation ratio on the osteogenic differentiation of murine bone marrow mesenchymal stem cells (mMSCs) were evaluated. Finally, the in vivo assessment was conducted to verify the polarization of macrophage and osteogenesis of SrMNBG through in situ bone defect repair experiment. The in vitro results showed that compared with 0%SrMNBG，SrMNBG with 5%, 10% and 15% molar percent of strontium element could further promote macrophage polarization toward M2, and 10%SrMNBG displayed the best effect. Moreover, the secretion of macrophages modulated by 10%SrMNBG was more beneficial to osteogenesis. The in vivo results showed that there were more M2 macrophages around 10%SrMNBG after implantation in the body, and better bone repair effect was found in the 10%SrMNBG group, which were consistent with the in vitro results. Therefore, SrMNBG is expected to be a promising immunoregulatory material for bone repair.