甘氨酸络氨酸苯丙氨酸（glycinetyrosinephenylalanine，GYF）结构域是一种小型的、能识别富脯氨酸序列（proline rich sequences，PRS）的保守、多功能接合结构域，GYF结构域蛋白在蛋白蛋白相互作用、翻译起始、mRNA剪接、监管与翻译抑制、泛素连接、信号转导、免疫蛋白酶调控等方面起重要作用。本文从结构域特性、与靶蛋白的相互作用及其功能等方面综述GYF结构域蛋白的研究进展。

GYF domains are small, conservative, versatile adaptor domains that recognize prolinerich sequences (PRS). GYF domain proteins play important roles in protein protein interaction, translational initiation, mRNA splicing, surveillance and translation suppression, ubiquitin ligation, signal transduction and immune protease regulation, et al. The study progress of GYF domain protein on aspects of domain characters, interaction with target proteins as well as its function were reviewed in the paper.