Abstract：Nongadoliniumbased T1 contrast agents have attracted great interest in recent years. In this work, (3.02±0.62) nm zincdoped iron oxide nanoparticles (ZnFe2O4) with a high r1 relaxivity of 2.5 L/（mmol·s） and low r2/r1 ratio of 2.2 are synthesized using a onepot thermal decomposition process. The synthetic procedure is simple, cost effective, and easy to scale up. The nanoparticles are modified with a biologically compatible ligand POPEG. Due to the hydrophilic polymer coating, the particles are highly dispersible and stable in aqueous solution. Finally, we applied the nanoparticles to in vivo magnetic resonance imaging and obtained a relative signal enhancement of 11% at the tumor region. This study revealed ZnFe2O4@PO-PEG as a potential candidate for a nongadoliniumbased T1 contrast agent with extraordinary biosafety.
引用本文:
韩佳媚， 梁国海. 基于超微小ZnFe2O4纳米颗粒的新型T1造影剂的制备及应用研究[J]. 激光生物学报, 2018, 27(4): 313-319.
HAN Jiamei, LIANG Guohai. Preparation and Application of Ultrasmall ZnFe2O4 NanoparticlesBased T1 MRI Contrast Agent. journal1, 2018, 27(4): 313-319.
