摘　要：钙黏蛋白-16 （CDH-16）是非典型的钙黏蛋白超家族成员，其表达具有明显的时空特异性，主要分布在肾脏和甲状腺，Cdh-16转录产物也暂时性出现在小鼠胚胎时期的生殖管道和肺上皮。迄今为止的研究表明，CDH-16与组织完整性、胚胎发育密切相关，并参与维持组织正常代谢、影响癌症发生等过程，但其具体的作用机制仍不清楚。本文对CDH-16的结构、功能、组织分布及其基因表达的时空调控进行了综述，以期为将来更深入地探究这一蛋白在不同生物学进程中的作用机制提供理论基础。
关键词：钙黏蛋白-16；组织分布；细胞黏连；肿瘤；代谢异常
中图分类号：Q51；Q71                          文献标志码：ADOI：10.3969/j.issn.1007-7146.2022.01.001

Abstract: Cadherin-16 (CDH-16) is an atypical member of cadherin superfamily with specific spatio-temporal expression pattern. It is mainly detected in the kidney and the thyroid, and its transcription products transiently appear in the sex ducts, as well as lung epithelium of mouse embryos. Studies to date show that CDH-16 contributes to the maintenance of tissue integrity and embryonic development, and is also involved in normal tissue metabolism and carcinogenesis process, whereas the underlying mechanism of its action remains largely unknown. Herein, this review summarizes the structure, function, distribution of CDH-16, as well as its spatio-temporal regulation of Cdh-16 gene expression, which provide theoretical basis for uncovering the role of CDH-16 protein in different biological processes.
Key words: CDH-16; tissue distribution; cell adhesion; tumor; metabolic abnormalities
（Acta Laser Biology Sinica, 2022, 31(1): 001-006）