Liposome Coated Mesoporous Carbon Nanotube with Resveratrol Loading for Targeted and Near-infrared Laser-triggered Chemo/Photothermal Synergistic Cancer Therapy
Abstract:Abstract: Resveratrol (Res) is a promising molecule for fighting cancer. However, the potential of the drug is immensely hindered by several limiting factors, including poor water solubility, limited chemical stability, and low bioavailability. In order to solve the above problems, we report a facile synthesis of a Res-loaded folate-terminated PEG-liposome (FA-PEG-Lip) coated mesoporous carbon nanotube (MCN) nanosystem (FA-PEG-Lip@MCN/Res) by simply sonicating Res and MCN in FA-PEG-Lip suspensions. The as-obtained FA-PEG-Lip@MCN/Res exhibits a nanoscale size [width: (80±10) nm, length: (600±100) nm], a negative surface potential (-10.2 mV), an excellent drug loading (131.59 mg/g MCN), good monodispersity and near infrared (NIR) laser stimulation-response release. Owing to folate receptor-mediated targeted delivery, the FA-PEG-Lip@MCN/Res nanosystem can deliver loaded Res to human breast cancer MCF-7 cells with high specificity. The cell toxicity viability shows that unloaded FA-PEG-Lip@MCN has no cytotoxicity, confirming its suitability as a drug vehicle. In addition, a systematic in vitro and in vivo experiments demonstrated that, under NIR laser irradiation, the FA-PEG-Lip@MCN/Res nanosystem exhibits highly efficient chemotherapy/photothermal synergistic therapy. All in all, the FA-PEG-Lip@MCN/Res nanosystem can simultaneously improve Res water solubility, enhance Res stability, extend plasma half-life of Res in mice, folate receptor targeting, NIR laser stimulation-response release, and synergistic tumor therapy, which may greatly promote the application of Res in clinical practice.
Key words: resveratrol; mesoporous carbon nanotube; nanoliposomes; chemo/photothermal synergistic therapy; folate targeting
引用本文:
李 璟,伍 旭,彭 倩,王晨旭,杨 凡. 基于装载白藜芦醇的脂质体包裹介孔碳纳米管用于靶向及近红外激光触发的化疗/光热协同肿瘤治疗[J]. 激光生物学报, 2020, 29(6): 550-560.
LI Jing, WU Xu, PENG Qian, WANG Chenxu, YANG Fan. Liposome Coated Mesoporous Carbon Nanotube with Resveratrol Loading for Targeted and Near-infrared Laser-triggered Chemo/Photothermal Synergistic Cancer Therapy. journal1, 2020, 29(6): 550-560.