Abstract：A rapid and noninvasive method based on surfaceenhanced Raman spectroscopy （SERS) was developed to diagnose congestion degree of coronary arteries prospectively by detecting plateletderived growth factorBB （PDGF-BB) in urine samples in our previous research. This work was to investigate whether the developed method could be applied to the patients on longterm medication including aspirin, rosuvastatin, clopidogrel bisulfate, and postPCI patients for the diagnosis of congestion degree of coronary arteries. Firstly, urine samples from 13 patients on longterm medication and from 13 postPCI patients were measured based on the developed method. It was found that there was no Raman peak at 1 509 cm-1 attributed to PDGFBB in these SERS spectra. In addition, further investigation of SERS spectra of aqueous solutions of PDGF-BB mixed with three kinds of drugs was conducted. There was no Raman peak at 1 509 cm-1 in these three spectra as well. It turned out that these drugs had impact on the SERS signal of PDGFBB, and this method was not suitable for the detection of congestion degree of coronary arteries for patients on longterm medication and postPCI patients.
