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Abstract Abstract: Hepatic hemangioma is one of the common benign tumors, which is treated with Chaihu Shugan Powder in clinical, but its specific mechanism of action is still unknown. In this study, network pharmacology and molecular docking methods were used to obtain the information of key targets and components through the analysis of the compositional target network diagram, and molecular docking of key targets and components was carried out to obtain the corresponding molecular docking map and explore the mechanism of action. A total of 142 ingredients of Chaihu Shugan Powder were obtained, and 61 targets were intersections with hepatic hemangioma. There were 184 biological processes for gene ontology (GO) functional enrichment, which mainly involving transcription factor activity, DNA binding, and positive regulation of transcription. 138 signaling pathways were identified by Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis, which mainly involve PI3K-Akt signaling pathway, Hepatitis B signaling pathway, MAPK signaling pathway, and AGE-RAGE signaling pathway, etc. Molecular docking showed that AKT1 protein was stable with β-sitosterol, VEGFA protein was stable with quercetin and isorhamnetin, ESR1 and MAPK3 were stable with β-sitosterol and naringin, respectively. The mechanism of Chaihu Shugan Powder in the treatment of hepatic hemangioma may be related to inducing angiogenesis and protecting the activation of blood vessels and liver cells, in which active ingredients such as quercetin, isorhamnetin, β-sitosterol, kaempferol and naringin, through act on targets such as STAT3, AKT1, VEGFA, ESR1 and MAPK3, which has provided theoretical reference for clinical aplication.
Key words: Chaihu Shugan Powder; hepatic hemangioma; network pharmacology; molecular docking; signal pathway
（Acta Laser Biology Sinica, 2023, 32(2): 184-192）
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