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Abstract Abstract: The purpose of this study is to investigate the expression of non-metastatic cell 1 (NME1) in skin cutaneous melanoma (SKCM) and its correlation with clinical prognosis. The expression of NME1 in SKCM was analyzed using GEPIA database and UALCAN database. GSCA database, GEPIA database and TIMER database were used to analyze the relationship between the expression of NME1 and the overall survival rate of SKCM patients. The mutation of NME1 in SKCM and its correlation with the overall survival rate of SKCM patients were analyzed through cBioPortal database. The proteins that may interact with NME1 were analyzed by STRING database, and their functions were enriched by Metascape database. The correlation between the expression of NME1 and immune cells infiltration level in SKCM was analyzed using TIMER database. The results showed that the expression of NME1 in SKCM was significantly higher than that in normal tissues. The high expression of NME1 was significantly related to the lower overall survival rate of metastatic SKCM patients. NME1 gene mutation has no significant correlation with the overall survival rate of SKCM patients. NME1 and its interacting proteins are mainly involved in ARF6 trafficking pathway, purine metabolism, regulation of cell development, DNA metabolic process and other biological processes. The high expression of NME1 in metastatic SKCM was significantly correlated with the lower infiltration level of CD4+T cell, CD8+T cell, neutrophil, macrophage and dendritic cell. This study shows that the high expression of NME1 is related to the lower level of immune infiltrating cells, and the overall survival rate in patients with metastatic SKCM. NME1 is expected to become a biomarker related to the infiltration of immune cells and prognosis of metastatic SKCM.
Key words: SKCM; NME1; immune infiltration; clinical prognosis
（Acta Laser Biology Sinica, 2023, 32(2): 177-183）
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