Abstract：For finding on the new function of the product Yeast Mannan (Man) which made in our ADFLab and it is from the wasted beer yeast of the beerfactory. We did more research about the structure, property and the bioactivity of the Man. And then, we modified the structure of the Man by sulfated to get new product sulfatedMan (Mansulfated). The results show that the Mansulfated had some new bioactivity, which: 1) is no cytotoxin for the host C8166 cells which belong to human T lymphocyte system; and 2) can inhibit the virus of HIV1 cell growing in vitro. But the experiment results also show that the degree of the inhibit to the HIV1 virus cell growing by the Mansulfated is relation with the kinds of sulfated regents and the experiment methods, temperature, and cause effect of modified structure and construction of Man in different degree and then to produce differential biological function of Mansulfated product.
