Abstract：Abstract: Methyltransferases (MTs) are a class of enzymes that are ubiquitous in biological organisms, usually using S-adenosylmethionine as a methyl donor to catalyze the methylation reaction of the substrate. The heterologous expression of MTs in microorganisms has made great progress in realizing the biosynthesis of some important natural products. MTs can be used in microorganisms to synthesize important natural products such as phenylpropanoids, fragrance compounds, hormones and antibiotics. MTs have also been widely used in many fields such as medicine, chemical industry and energy, showing great application value and broad application prospects. In this review, we summarize the classification, function and application of natural product methyltransferases, in order to provide theoretical guidance for the efficient artificial biosynthesis of highly active non-ribosomal peptide synthetase (RXPs) peptides.
Key words: methyltransferases; S-adenosylmethionine; methylation; natural products; biosynthesis
（Acta Laser Biology Sinica, 2024, 33(5): 432-438）
引用本文:
陈美英，谢宇恒，唐苗苗，席雪冬. 天然产物合成过程中的甲基化酶修饰的研究进展[J]. 激光生物学报, 2024, 33(5): 432-438.
CHEN Meiying, XIE Yuheng, TANG Miaomiao, XI Xuedong. Research Progress on Methylase Modification in the Synthesis of Natural Products#br#. journal1, 2024, 33(5): 432-438.
