L-methionine Biosynthesis and Regulatory Mechanisms in Bacteria
(State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China)
Abstract：Abstract: L-methionine is an essential amino acid with a wide range of applications in food, feed, cosmetics and pharmaceuticals. Currently, L-methionine is the only essential amino acid that cannot be industrially produced by microbial fermentation. In recent years, the use of metabolic engineering to enhance the yield of L-methionine has received widespread attention from researchers at home and abroad. In this paper, the biosynthetic pathway and regulatory mechanism of L-methionine in Corynebacterium glutamicum and Escherichia coli are analysed; three key steps (i.e., acylation, sulfurylation, and methylation) in the biosynthesis of methionine from hyper-serine are highlighted, and a further outlook on the biosynthesis of L-methionine is proposed with a view to providing guidance for the industrial production of L-methionine.
Key words: L-methionine; biosynthesis; regulatory mechanism
（Acta Laser Biology Sinica, 2024, 33(5): 408-417）
引用本文:
崔 莹，宋 凯，何亚文. 细菌中L-甲硫氨酸生物合成和调控机制[J]. 激光生物学报, 2024, 33(5): 408-417.
CUI Ying, SONG Kai, HE Yawen. L-methionine Biosynthesis and Regulatory Mechanisms in Bacteria. journal1, 2024, 33(5): 408-417.
