Abstract:Nuclear receptor subfamily 6 group member1 (Nr6a1) is an active ligand transcription factor member of the nuclear receptor superfamily, also known as germ cell nuclear factor (GCNF) or retinoic acid receptorrelated testisassociated receptor (RTR). As a transcription factor, Nr6a1 plays a role of transcriptional inhibition by binding to the DR0 element (TCAAGGTCA) in the target gene promoter region. Nr6a1 is mainly expressed in mature germ cells, differentiated embryonic stem cells and germ cell tumors such〖JP1〗 as teratoma, which suggested that the expression profile of Nr6a1 is spatiotemporal specificity and tissue specificity. To date, a number of upstream or downstream of Nr6a1 regulatory molecules including miR181a, let7, Oct4, PPARδ have been identified. Through the interactions with these genes, Nr6a1 plays an important regulating role in biological processes of development, cell differentiation and metabolism.
引用本文:
刘晓雯,刘华伟,王伟龙,李〓丹. 孤儿核受体Nr6a1的生物学功能与表达调控机制[J]. 激光生物学报, 2018, 27(3): 199-204.
LIU Xiaowen, LIU Huawei, WANG Weilong, LI Dan. Biological Function and Expression Regulation Mechanism of Orphan Nuclear Receptor Nr6a1. journal1, 2018, 27(3): 199-204.