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Abstract (1. Carbon Negative Synthetic Biology for Biomaterial Production from CO2, Campus for Research Excellence and Technological Enterprise, SJTU Asia-Pacific Graduate Institute, Singapore 138602, Singapore; 2. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China)
Abstract: Carbon-negative synthetic biology aims to directly capture CO2 to produce bio-products. This technique not only solves the “food vs. fuel” dilemma in traditional biological production, but also achieves CO2 peaking and carbon neutrality, therefore, it has obvious economic, ecological, and social benefits. Cyanobacteria, which use light energy to convert CO2 into biomass, are ideal chassis cells in CNSB. The newly discovered Synechococcus sp. PCC 11901 is a robust cyanobacterial strain with high resistance to salt and light, fast growth and big biomass, and multiple genetic toolbox available, representing a rising star among the cyanobacterial chassis cells. This review summarized the research progress in PCC 11901, including its morphology, biochemical and physiological features, genomic characteristics, available genetic toolboxes, and bio-products derived from engineered PCC 11901, with the aim of providing theoretical references for future research related to PCC 11901.
Key words: cyanobacterium; Synechococcus sp. PCC 11901; growth and biomass; genetic manipulation; carbon-negative synthetic biology
（Acta Laser Biology Sinica, 2024, 33(6): 489-495）
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