Abstract：The object of this study was to investigate the effects of oral administration with glutamate on organ indices, blood biochemical indexes, blood lipid levels and antioxidant capacities of the suckling piglets Fortyeight healthy piglets (Duroc ×Large White × Landrace; 1 d of age) with similar initial weight and birth date (155±020 kg; 1 d of age) were selected from six sows (8 piglets per sow) and randomly assigned to 4 dietary groups in terms of body weight (BW) Pigltes were marked by ear tags after birth The piglets were oral administration with 018 g/kg BW of sodium chloride (CN group), 006 g/kg BW monosodium glutamate (LMG group), 050 g/kg BW monosodium glutamate (MMG group) and 100 g/kg BW monosodium glutamate (HMG group), respectively On day 7 of the trial, one piglet was randomly selected from each group, and the samples were collected after blood collection, and the others were slaughtered on the day 21 The results showed that there were no significant differences on the heart, liver, spleen and kidney index at day 7 and day 21 Oral administration with high dose of glutamate increased serum glutamine synthetase activity and hemoglobin content in suckling piglets on day 7 as well as serum glutamine synthetase activity on day 21 Serum endotoxin ET content and ATPase activity in sucking piglets were significantly reduced by oral administration with high dose of glutamate Oral administration with medium dose of glutamate reduced the serum free fatty acid content on day 7 and 21, and also affected the serum HDL levels on 21 days Oral administration with medium dose of glutamate increased serum total antioxidant capacity and reduced the activities of serum glutathione transferase and superoxide dismutase and the content of malondialdehyde on day 7 On day 21, the MMG and HMG groups had lower serum glutathione transferase activity and malondialdehyde content and greater serum superoxide dismutase activity than CN group The results of the present experiment indicate that oral administration with glutamate can affect blood biochemical indices, blood lipid levels and improve the antioxidant capacities of suckling piglets
