Abstract:Eighty four patients with cafeaulait were treated with Qswitched 532 nm or 755 nm laser randomly by our center. The clinical efficacy was assessed. 36 patients were treated with Qswitched 532 nm laser, 10 patients were completely cured (27.8%), 10 patients were significantly improved (27.8%), 8 improved (22.2%) and 8 invalid (22.2%); 48 patients were treated with Qswitched 755 nm laser, 14 patients were cured completely (29.2%), 13 patients were significantly improved (27.1%), 11 improved (22.9%) and 10 invalid (20.8%). Of the 84 patients, total effective rate is 78.6%. After 6 months of followup, 9 patients appeared pigmentation, 3 patients appeared hypopigmentation and 9 recrudesced. The effective rate of cafeaulait with regular shape is 52.5%, and irregular shape is 79.5%, there was a significant difference between two teams (P<0.05). There was no significant difference in efficacy between Qswitched 532 nm and 755 nm laser (P>0.05). The above results showed Qswitched 532 nm and 755 nm laser were effective agents for treatment of cafeaulait.,and the efficacy of Qswitched laser on cafeaulait with regular shape is better than those with irregular shape.