Abstract：Abstract: Based on bioinformatics analysis, a transcription factor FOXM1-derived tumor antigen peptide M1-10 was screened out. Through the experiments of lymphocyte proliferation, interferon gamma release, and cell killing, we found that M1-10 peptide could stimulate the immune memory in vivo and produce better effects when combined with HJURP, MELK, VEGFR1, and VEGFR2-derived four antigens. Tumor pre-immunization experiments were carried out with the mouse models of grafted breast cancer and MMTV-PyMT primary breast cancer. Compared with the control group, M1-10 alone produced significant anti-tumor effects, and M1-10 plus four antigen generated stronger anti-tumor effects. In conclusion, the study developed the tumor antigen peptide M1-10 with a strong immunogenicity, which could result in effective tumor immunity when used alone or combined with other tumor antigen peptides. This conclusion provides further insights into the antitumor mechanism of FOXM1.
Key words: tumor antigen peptide M1-10; transcription factor FOXM1; immune memory; tumor immunity; mouse
（Acta Laser Biology Sinica, 2022, 31(2): 121-128）
引用本文:
黄文强，卜会铜，裴超柱，黄明敏，谭拥军. 肿瘤抗原肽M1-10的抑瘤活性研究[J]. 激光生物学报, 2022, 31(2): 121-128.
HUANG Wenqiang, BU Huitong, PEI Chaozhu, HUANG Mingmin, TAN Yongjun. The Anti-tumor Activities of Tumor Antigen Peptide M1-10. journal1, 2022, 31(2): 121-128.
