Abstract:Abstract: All the living organisms can synthesize various fatty acids, which exist in different carbon chain length, configurations and biological functions. These fatty acids are involved in many important physiological activities including anabolism, energy metabolism, and signal transduction. The living organisms are also capable of degrading and utilizing fatty acids via different oxidative pathways and β-oxidation is one of the most important oxidative pathways in both prokaryotic and eukaryotic cells. Research in the model organism Escherichia coli has provided the most complete view of fatty acids β-oxidation. In this review, the progress of fatty acids β-oxidation in E. coli and other bacterial species were summarized. By taking the phytopathogen Xanthomonas as an example, this review then introduced the oxidation pathway and regulation mechanism of the diffusible signaling factor (DSF)-family quorum sensing signal (mid-chain unsaturated fatty acids). Based on current results, the specific enzymes required for β-oxidation of very-long-chain fatty acids, 3-methyl-fatty acids, Δ2/Δ3-unsaturated fatty acids, and polyunsaturated fatty acids were proposed. Finally, the key scientific questions to be answered in this field were prospected. This review provides a solid foundation for further study of fatty acid β-oxidation pathway and the underlying mechanisms of bacterial pathogenicity.
Key words: bacteria; fatty acid; β-oxidation; DSF-family quorum sensing signal; bacterial pathogenicity
(Acta Laser Biology Sinica, 2021, 30(6): 494-504)
引用本文:
王智勇,宋 凯,郝祥蕊,张红艳,何亚文. 细菌中脂肪酸β-氧化途径与机理的研究进展[J]. 激光生物学报, 2021, 30(6): 494-504.
WANG Zhiyong, SONG Kai, HAO Xiangrui, ZHANG Hongyan, HE Yawen. Advances in Pathways and Mechanisms of Fatty Acid β-oxidation in Bacteria. journal1, 2021, 30(6): 494-504.