Abstract：Abstract: In order to further study the mechanism of chemotherapy resistance in human gliomas and explore potential therapeutic methods, we investigated the effects of tumor necrosis factor α-induced protein 1 (TNFAIP1) on migration and invasion. Reverse transcription PCR and Western blot assays showed that temozolomide increased the expression of TNFAIP1. We overexpressed TNFAIP1 in U251 cells, then we found it could promote the inhibition of temozolomide (TMZ) on migration and invasion of U251 cells, and this effect was achieved by inhibiting epithelial-to-mesenchymal transition (EMT) signaling pathway. This finding is helpful to provide a new theoretical basis for clinical treatment of human glioma and provide a new strategy for its treatment.
Key words: human glioma; TNFAIP1; TMZ; cell invasion; EMT
（Acta Laser Biology Sinica, 2021, 30(2): 178-184）
引用本文:
许斐钰，陈 果，龙胜文，魏晨曦. 过表达TNFAIP1促进替莫唑胺对人脑胶质瘤细胞U251迁移和侵袭的抑制作用[J]. 激光生物学报, 2021, 30(2): 178-184.
XU Feiyu, CHEN Guo, LONG Shengwen, WEI Chenxi. Overexpression of TNFAIP1 Promote the Inhibitory Effect of Temozolomide on Migration and Invasion of Glioma Cells U251#br#. journal1, 2021, 30(2): 178-184.
