pH- and NIR Laser Dual-Responsive Metal-Organic Frameworks ZIF-8 with MoS2 Nanosheets and DOX Loading for Chemo/Photothermal Synergistic Cancer Therapy
Abstract：Here, we report a novel metal-organic framework ZIF-8based nanocomposite with encapsulated molybdenum disulfide(MoS2)nanosheets and doxorubicin(DOX)for pH- and NIR-triggered synergistic chemo/photothermal treatment of cancer cells. First, MoS2 nanosheets, which have uniform size of ~100 nm and topological height of 0.3~1.4 nm, are synthesized by hydrothermal reaction and ultrasonic treatment. Subsequently,an aciddegradable metalorganic framework ZIF-8 is employed to synchronously encapsulate MoS2 nanosheets and anticancer drug DOX to obtain DOX loaded ZIF-8 coated MoS2 (DOX/MoS2@ZIF-8)nanocomposites by onestep method. The nanocomposites are used for chemo/photothermal synergistic treatment of cancer cells: under acid conditions (e.g. pH 5.0 in a lysosome)and NIR laser irradiation (780 nm, 2.1 W/cm2), the ZIF-8 of the DOX/MoS2@ZIF-8 nanocomposites can be degraded, resulting in the release of encapsulated DOX, the cytosolic DOX can enter the nucleus to induce apoptosis. Meanwhile, the MoS2 nanosheets can effectively convert NIR laser light energy into heat energy, the photoinduced hyperthermia can also induce apoptosis. Thus, chemo/photothermal synergistic cancer therapy is realized. Cell viability assays show that this DOX/MoS2@ZIF-8 nanocomposites have an excellent chemo/photothermal synergistic treatment effect on SMMC7721 cells, which can kill the tumor cells efficiently.
引用本文:
李 璟，彭 倩，王丽姣，王晨旭，杨 凡. pH和近红外光双响应的包裹二硫化钼纳米片和阿霉素的金属-有机框架ZIF-8用于肿瘤化学/光热协同治疗[J]. 激光生物学报, 2019, 28(5): 421-430.
LI Jing, PENG Qian, WANG Lijiao, WANG Chenxu, YANG Fan. pH- and NIR Laser Dual-Responsive Metal-Organic Frameworks ZIF-8 with MoS2 Nanosheets and DOX Loading for Chemo/Photothermal Synergistic Cancer Therapy. journal1, 2019, 28(5): 421-430.
